منابع مشابه
From microbial to lens βγ-crystallins: Presence of a universal calcium-binding motif in βγ-crystallin superfamily
Crystallins which form the major protein components of the eye lens are responsible for its transparency. βγ-crystallin superfamily has a well-characterized protein fold which is present in several members in prokaryotes and eukaryotes. Apart from two members from eukaryote, Spherulin 3a and Ciona crystallin, a majority of them possess the two or more βγ-crystallin domains. The βγ domain consis...
متن کاملStructural Integrity of the Greek Key Motif in βγ-Crystallins Is Vital for Central Eye Lens Transparency
BACKGROUND We highlight an unrecognized physiological role for the Greek key motif, an evolutionarily conserved super-secondary structural topology of the βγ-crystallins. These proteins constitute the bulk of the human eye lens, packed at very high concentrations in a compact, globular, short-range order, generating transparency. Congenital cataract (affecting 400,000 newborns yearly worldwide)...
متن کاملEnhanced Bioadsorption of Cadmium and Nickel by E. coli Displaying A Metal Binding Motif Using CS3 Fimbriae
Display of peptides on the surface of bacteria offers many new and exciting applications in biotechnology. Fimbriae is a good candidate for epitope display on the surface of bacteria. The potential of CS3 fimbriae of enterotoxigenic E. coli as a display system has been investigated. A novel cell surface display system with metal binding property was developed by using CS3 fimbriae. Short metal ...
متن کاملPrimary sequence contribution to the optical function of the eye lens
The crystallins have relatively high refractive increments compared to other proteins. The Greek key motif in βγ-crystallins was compared with that in other proteins, using predictive analysis from a protein database, to see whether this may be related to the refractive increment. Crystallins with Greek keys motifs have significantly higher refractive increments and more salt bridges than other...
متن کاملDiscovering Transcription Factor Binding Motif Sequences
Introduction In biology, sequence motifs are short sequence patterns, usually with fixed lengths, that represent many features of DNA, RNA, and protein molecules. Sequence motifs can represent transcription factor binding sites for DNA, splice junctions for RNA, and binding domains for proteins. Thus, discovering sequence motifs can lead to a better understanding of transcriptional regulation, ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2014
ISSN: 0021-9258
DOI: 10.1074/jbc.o113.539569